ORCiD: 0000-0002-5154-3318

Lab Members in Purple

2025

  1. Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish.
    Nature Communications
    bioRxiv
    Sema Elif Eski, Jiarui Mi, Macarena Pozo-Morales, Gabriel Garnik Hovhannisyan, Camille Perazzolo, Rita Manco, Imane Ez-Zammoury, Dev Barbhaya, Anne Lefort, Frederick Libert, Federico Marini, Esteban N. Gurzov, Olov Andersson, Sumeet Pal Singh

  2. Feeding induces c-Fos in hepatocytes contributing to hepatocellular carcinoma in obesity.
    bioRxiv
    Ao Li, Eduardo H Gilglioni, Wadsen St-Pierre-Wijckmans, Leila Hosseinzadeh, Christelle Veyrat-Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N Gurzov

  3. Volumetric imaging and single-cell RNAseq atlases identify cellular mechanisms of human dental pulp response during tooth decay progression.
    bioRxiv
    Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Kerem Ozen, Ines Tekia, Hugo Bussy, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N Gurzov, Sumeet Pal Singh, Nicolas Baeyens

  4. Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish.
    bioRxiv
    Nora John, Thomas Fleming, Julia Kolb, Olga Lyraki, Sebastian Vasquez-Sepulveda, Asha Parmar, Kyoohyun Kim, Maria Tarczewska, Kanwarpal Singh, Federico Marini, Sumeet Pal Singh, Sven Falk, Kristian Franze, Jochen Guck, Daniel Wehner

  5. Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk.
    The EMBO Journal
    Mohammad Nadeem Akhtar, Alisa Hnatiuk, Luis Delgadillo-Silva, Shirin Geravandi, Katrin Sameith, Susanne Reinhardt, Katja Bernhardt, Sumeet Pal Singh, Kathrin Maedler, Lutz Brusch, Nikolay Ninov

2024

  1. Epigenetic Disordering Drives Stemness, Senescence Escape and Tumor Heterogeneity.
    bioRxiv
    Elena Magnani, Filippo Macchi, Tijana Randic, Charlene Chen, Bhavani Madakashira, Shashi Ranjan, Sema Elif Eski, Sumeet Pal Singh, Kirsten C. Sadler

  2. Fluorescent Tagging of Endogenous FOXO for Live Imaging and Pull-Down Assays.
    Book Chapter - FOXO Transcription Factors: Methods and Protocols
    Inés Garteizgogeascoa Suñer, Sumeet Pal Singh

  3. PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity.
    Nature Communications
    bioRxiv
    Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh, Joris Messens, Milos R. Filipovic, Hayley J. Sharpe, Eric Trépo, Wei Wu, Esteban N. Gurzov

  4. Computational Analysis of Calcium Flux Data Using R.
    Book Chapter - Calcium Signaling: Methods and Protocols
    Macarena Pozo-Morales, Sumeet Pal Singh

  5. Optogenetic β cell interrogation in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by vitamin B6.
    Science Advances
    Luis Fernando Delgadillo-Silva, Emirhan Tasöz, Sumeet Pal Singh, Prateek Chawla, Eleni Georgiadou, Anne Gompf, Guy A. Rutter, Nikolay Ninov


    LSA_Cover
  6. Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
    Life Science Alliance
    bioRxiv
    Macarena Pozo-Morales*, Ansa E Cobham*, Cielo Centola, Mary Cathleen McKinney, Peiduo Liu, Camille Perazzolo, Anne Lefort, Frederick Libert, Hua Bai, Nicolas Rohner§, Sumeet Pal Singh§
    * Co-Authors
    § Co-Corresponding author

    News Coverage:
    New Scientist: Blind cave fish offers lessons in how to survive starvation
    Yahoo! Finance: Overeating and starving both damage the liver: Cavefish provide new insight into fatty liver disease

  7. CD38 promotes hematopoietic stem cell dormancy via c-Fos.
    PLoS Biology
    bioRxiv
    Liliia Ibneeva, Sumeet Pal Singh, Anupam Sinha, Sema Elif Eski, Rebekka Wehner, Luise Rupp, Iryna Kovtun, Juan Alberto Perez-Valencia, Alexander Gerbaulet, Susanne Reinhardt, Manja Wobus, Malte von Bonin, Jaime Sancho, Frances Lund, Andreas Dahl, Marc Schmitz, Martin Bornhaeuser, Triantafyllos Chavakis, Ben Wielockx, Tatyana Grinenko

  8. HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes.
    iScience
    Valerie Vandenbempt, Sema Elif Eski, Manoja K. Brahma, Ao Li, Javier Negueruela, Ylke Bruggeman, Stéphane Demine, Peng Xiao, Alessandra K. Cardozo, Nicolas Baeyens, Luciano G. Martelotto, Sumeet Pal Singh, Eliana Mariño, Conny Gysemans, Esteban N. Gurzov

2023

  1. Cellular senescence modulates progenitor cell expansion during axolotl limb regeneration.
    Developmental Cell
    bioRxiv
    Qinghao Yu, Hannah E. Walters, Giovanni Pasquini, Sumeet Pal Singh, Daniel León-Periñán, Andreas Petzold, Preethi Kesavan, Cristina Subiran, Ines Garteizgogeascoa, Dunja Knapp, Anne Wagner, Andrea Bernardos, María Alfonso, Gayathri Nadar, Andreas Dahl, Volker Busskamp, Ramón Martínez-Máñez, Maximina H. Yun

  2. Fluorescent Sensors for Imaging Interstitial Calcium.
    Nature Communications
    bioRxiv
    Ariel A. Valiente-Gabioud, Inés Garteizgogeascoa Suñer, Agata Idziak, Arne Fabritius,Jérome Basquin, Julie Angibaud, U. Valentin Nägerl, Sumeet Pal Singh, Oliver Griesbeck

  3. A zebrafish knock-in reporter line for the Foxo1a transcription factor.
    bioRxiv
    Inés Garteizgogeascoa Suñer, Sumeet Pal Singh

  4. Editorial: Emerging Technologies in Thyroid Biology: Pushing the Frontiers of Thyroid Research.
    Molecular and Cellular Endocrinology
    Sabine Costagliola and Sumeet Pal Singh

  5. In vivo imaging of calcium dynamics in zebrafish hepatocytes.
    Hepatology
    bioRxiv
    Macarena Pozo-Morales, Inés Garteizgogeascoa, Camille Perazzolo, Juhoon So, Donghun Shin, Sumeet Pal Singh

2022

  1. Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism.
    Nature Communications
    bioRxiv
    Mirian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff, Sabine Costagliola

  2. Loss of tetraspanin-7 expression reduces pancreatic beta-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism.
    Diabetic Medicine
    Kerry McLaughlin, Samuel Acreman, Sameena Nawaz, Joseph Cutteridge, Anne Clark, Jakob G. Knudsen, Geoffrey Denwood, Aliya F. Spigelman, Jocelyn E. Manning Fox, Sumeet Pal Singh, Patrick E. MacDonald, Benoit Hastoy, Quan Zhang

  3. NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes.
    Cell Death & Disease
    Peng Xiao, Tatiana Takiishi, Natalia Moretti Violato, Giada Licata, Francesco Dotta, Guido Sebastiani, Lorella Marselli, Sumeet Pal Singh, Mozes Sze, Geert Van Loo, Emmanuel Dejardin, Esteban Nicolas Gurzov & Alessandra Kupper Cardozo

  4. Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids.
    bioRxiv
    Barbara F. Fonseca, Cindy Barbée, Mirian Romitti, Sema Elif Eski, Pierre Gillotay, Daniel Monteyne, David Perez Morga, Samuel Refetoff, Sumeet Pal Singh, Sabine Costagliola

  5. Nrf2 promotes thyroid development and hormone synthesis.
    bioRxiv
    Gillotay Pierre, Romitti Mirian, Dassy Benjamin, Haerlingen Benoit, Parakkal Shankar Meghna, Faria Fonseca Barbara, Ziros G. Panos, Sumeet Pal Singh, Sykiotis P. Gerasimos, Sabine Costagliola

  6. Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo.
    The EMBO Journal
    bioRxiv
    Wallis Nahaboo, Sema Elif Eski, Evangéline Despin-Guitard, Marjorie Vermeersch, Marie Versaevel, Bechara Saykali, Daniel Monteyne, Sylvain Gabriele, Thomas M Magin, Nicole Schwarz, Rudolf E Leube, An Zwijsen, David Perez-Morga, Sumeet Pal Singh, Isabelle Migeotte

  7. A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ cells to diabetes recovery in zebrafish.
    Development
    bioRxiv
    Sumeet Pal Singh*, Prateek Chawla*, Alisa Hnatiuk, Margrit Kamel, Luis Delgadillo Silva, Bastiaan Spanjard, Sema Elif Eski, Sharan Janjuha, Pedro Olivares, Oezge Kayisoglu, Fabian Rost, Juliane Bläsche, Annekathrin Kränkel, Andreas Petzold, Thomas Kurth, Susanne Reinhardt, Jan Philipp Junker, Nikolay Ninov
    * Co-Authors

  8. PTPN2 regulates the interferon signalling and endoplasmic reticulum stress response in pancreatic β-cells in autoimmune diabetes.
    Diabetes
    Bernat Elvira, Valerie Vandenbempt, JuliaBauzá-Martinez, Raphaël Crutzen, Javier Negueruela, Hazem Ibrahim, Matthew Winder, Manoja Brahma, Beata Vekeriotaite, Pieter-Jan Martens, Sumeet Pal Singh, Fernando Rossello, Pascale Lybaert, Timo Otonkoski, Conny Gysemans, Wei Wu, Esteban Gurzov

2021

  1. Single-cell trajectory inference guided enhancement of thyroid maturation in vitro using TGF-beta inhibition
    Frontiers in Endocrinology
    bioRxiv
    Mirian Romitti§*, Sema Elif Eski*, Barbara Faria Fonseca, Sumeet Pal Singh§, Sabine Costagliola§
    * Co-Authors
    § Co-Corresponding author

  2. In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration
    eLife
    bioRxiv
    Mira I. Pronobis, Susan Zheng, Sumeet Pal Singh, Joseph A Goldman, Kenneth D. Poss

2020

EMBO_Cover

  1. Single-cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland
    EMBO reports
    bioRxiv
    Pierre Gillotay, Meghna P Shankar, Sema Elif Eski, Macarena Pozo-Morales, Inés Garteizgogeascoa, Susanne Reinhardt, Annekathrin Kraenkel, Juliane Blaesche, Andreas Petzold, Nikolay Ninov, Gokul Kesavan, Christian Lange, Michael Brand, Vincent Detours, Sabine Costagliola§, Sumeet Pal Singh§
    § Co-Corresponding author

  2. Asymmetry in the frequency and position of mitosis in the mouse embryo epiblast at gastrulation
    EMBO reports
    bioRxiv
    Navrita Mathiah, Evangeline Despin-Guitard, Matthew Stower, Wallis Nahaboo, Sema Elif Eski, Sumeet Pal Singh, Shankar Srinivas, Isabelle Migeotte

  3. Nuclei Isolation from Whole Tissue using a Detergent and Enzyme-Free Method
    Journal of Visualized Experiments
    Sema Elif Eski, Christine Dubois, Sumeet Pal Singh

  4. Transcriptional analysis of sepsis-induced activation and damage of the adrenal microvascular cells
    Frontiers in Endocrinology
    Lan-Sun Chen, Sumeet Pal Singh, Gregor Müller, Stefan R. Bornstein and Waldemar Kanczkowski

  5. Multicolor labeling and tracing of pancreatic beta-cell proliferation in zebrafish
    Book Chapter - Animal Models of Diabetes: Methods and Protocols
    Sumeet Pal Singh and Nikolay Ninov.

2019

  1. Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo
    Nature Metabolism
    Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S. Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C. A. Gaboriau, Stephen M. Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J. Pullen, Sumeet Pal Singh, David J. Hodson, Isabelle Leclerc, A. M. James Shapiro, Piero Marchetti, Linford J. B. Briant, Walter Distaso, Nikolay Ninov & Guy A. Rutter

  2. RNA-seq analysis of LPS-induced transcriptional changes and its possible implications for the adrenal gland dysregulation during sepsis
    The Journal of steroid biochemistry and molecular biology
    Lan-Sun Chen, Sumeet Pal Singh, Maria Schuster, Tatyana Grinenko, Stefan R. Bornstein, Waldemar Kanczkowski

2018

  1. Machine learning based classification of cells into chronological stages using single-cell transcriptomics
    Scientific Reports
    bioRxiv
    Sumeet Pal Singh§, Sharan Janjuha, Samata Chaudhuri, Susanne Reinhardt, Annekathrin Kränkel, Sevina Dietz, Anne Eugster, Halil Bilgin, Selçuk Korkmaz, Gökmen Zararsız, Nikolay Ninov & John E. Reid
    § Corresponding author

  2. In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone
    Current Biology
    Ben D. Cox, Alessandro De Simone, Valerie A. Tornini, Sumeet Pal Singh, Stefano Di Talia, Kenneth D. Poss

  3. Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets
    Journal of Visualized Experiments
    Sharan Janjuha*, Sumeet Pal Singh*, Nikolay Ninov
    * Co-Authors

  4. Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish
    eLife
    Sharan Janjuha*, Sumeet Pal Singh*, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov
    * Co-Authors

  5. The triumvirate of beta-cell regeneration: solutions and bottlenecks to curing diabetes
    The International journal of developmental biology
    Sumeet Pal Singh and Nikolay Ninov

2017

  1. Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
    Nature Communications
    Sumeet Pal Singh, Sharan Janjuha, Theresa Hartmann, Özge Kayisoglu, Judith Konantz, Sarah Birke, Priyanka Murawala, Ezzaldin Ahmed Alfar, Kei Murata, Anne Eugster, Naoki Tsuji, Edward R. Morrissey, Michael Brand & Nikolay Ninov

2016

  1. Tissue- and time-directed electroporation of CAS9 protein–gRNA complexes in vivo yields efficient multigene knockout for studying gene function in regeneration
    npj Regenerative Medicine
    Ji-Feng Fei, Dunja Knapp, Maritta Schuez, Prayag Murawala, Yan Zou, Sumeet Pal Singh, David Drechsel & Elly M Tanaka

2012

  1. Regeneration of amputated zebrafish fin rays from de novo osteoblasts
    Developmental Cell
    Sumeet Pal Singh, Jennifer E. Holdway, Kenneth D. Poss

2011

  1. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion
    Development
    Jinhu Wang, Daniela Panáková, Kazu Kikuchi, Jennifer E. Holdway, Matthew Gemberling, James S. Burris, Sumeet Pal Singh, Amy L. Dickson, Yi-Fan Lin, M. Khaled Sabeh, Andreas A. Werdich, Deborah Yelon, Calum A. MacRae, Kenneth D. Poss