Welcome to the Singh Lab
Our research is driven by a passion to uncover the fundamental mechanisms that govern liver health and regeneration. The liver stands as a unique organ with unparalleled regenerative capacity, capable of restoring itself after injury or stress. From the myth of Prometheus to modern medicine, the liver's resilience inspires our pursuit of understanding how organs recover and adapt under various conditions.
At the Singh Lab, we explore the dynamic interplay between cellular plasticity, organ repair, and stress-induced dysfunction. Our work spans key areas of liver biology, including the mechanisms driving regeneration during developmental growth spurts, the role of cholangiocyte-to-hepatocyte transdifferentiation, and the cellular responses to starvation-induced fatty liver and alcoholic liver disease. These diverse themes converge on a singular goal: to understand the robustness of biological systems and how they can be harnessed to improve outcomes in liver injury and disease.
We use zebrafish as a model organism, leveraging its remarkable regenerative abilities and the unique transparency of its larvae, which provides a real-time view of cellular dynamics during injury and stress. Advanced imaging techniques, state-of-the-art transcriptomics, gene editing, and transgenics are central to our approach, enabling us to ask and answer fundamental questions about regeneration and resilience.
Our lab combines curiosity-driven research with a vision to translate these insights into meaningful advances in liver health. Explore our work and publications to discover how we strive to decode the secrets of regeneration and resilience in biological systems.
We are situated in the Brussels, the capital of European Union. Feel free to contact us.